Drug delivery & wound dressing
The limited biocompatibility of drug often reduces its therapeutic efficacy, drug delivery system can be an effective solution for this issue.
Research publication highlights
Smoking-related poisoning treatment
Nephropathy in tobacco smoker is postulated to be caused by nicotine (Nic) and catalyzed by various heavy metals (M(II) = Ni(II), Pb(II), and Cd(II)) contained in commercial cigarettes. Once absorbed through the lungs, these compounds will eventually be ended in the kidney, and thus, trigger various diseases. Metal chelation therapy is known as one of the efficient treatments to reduce the level of toxic metal in intoxicated patients. Here the interaction tendency of Nic and heavy metals to form complexes was investigated at a physiological condition. The result suggests the possible usage of antioxidants for the simultaneous removal of Nic and heavy metals via the metal chelation principle.
Check out the article at Journal of Molecular Liquids 312 (2020) 113428
Conversion of cellulose into wound dressing
Bacterial contamination on external wounds is known to be a factor that prevents wound healing and triggers tissue damage. Hydrogel-dressings with antibacterial activity is a useful medical device to avoid this contamination, wherein the antibacterial activity can be provided via incorporation of silver nanoparticles (AgNPs). Contrary to the conventional two-step preparation of an AgNPs-loaded hydrogel (AgNPs@hydrogel), this work aims to establish a new and facile synthesis method employing the adsorption principle. The outcome of this work indicates that the addition of rarasaponin not only can increase the loading of AgNPs on cellulose carbamate hydrogel (CCH) but also significantly enhance the antibacterial activity of the resulted hydrogel-dressing. Furthermore, the cytotoxic test shows that the hydrogel-dressings have good biocompatibility toward skin fibroblast cells.
Check out the article at Materials Science and Engineering:C 118 (2021) 111542
Biocompatible & biodegradable drug carrier
Biodegradable product technology
Tuberculosis (TB) is a disease caused by the M. tuberculosis bacteria infection and is listed as one of the deadliest diseases to date. Despite the development of antituberculosis drugs, the need for long-term drug consumption and low patient commitment are obstacles to the success of TB treatment. A continuous drug delivery system that has a long-term effect is needed to reduce routine drug consumption intervals, suppress infection, and prevent the emergence of drug-resistant strains of M. tuberculosis. For this reason, biomolecule metal-organic framework (BioMOF) with good biocompatibility, nontoxicity, bioactivity, and high stability are becoming potential drug carriers. This study used a bioactive protocatechuic acid (PCA) as organic linker to prepare copper-based BioMOF Cu-PCA under base-modulated conditions.
Check out the article at Biomaterials Advances 146 (2023) 213269